The patients/participants provided their written informed consent to participate in this study. At first, I thought it could be a fungal infection like ringworm, a common misdiagnosis, says Hartman, but my dermatologist ruled that out when I mentioned the additional spots erupting on my back via our video chat. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. 2021;35(8):e489e491. Please enable it to take advantage of the complete set of features! Pityriasis rosea doesnt usually affect people over the age of 60. . Among the common cutaneous manifestations of COVID-19 (e.g., morbilliform eruptions, chilblains, and varicella-like vesicles), PR and PR-like eruptions have rarely been described (6, 7). Physicians should be aware that pityriasis rosea is a rare side-effect of COVID-19 vaccination.Pityriasis rosea is self-limiting and no medical treatment is usually required. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. sharing sensitive information, make sure youre on a federal doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Epub 2020 Nov 20. Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin. Get many smaller patches or bumps on your skin. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. At home, she underwent systemic treatment with antihistamines and topical medication with dermatocorticosteroids. Your symptoms dont improve after treatment. If you have pityriasis rosea, you dont have to avoid any foods or drinks. Nevertheless, the incidence of skin reactions after mRNA vaccinations was low. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. PMC Pityriasis rosea-like Covid-arm Erythema multiforme Erythroderma Psoriasis Others Grover-like eruptions Herpes simplex reactivation: 24 1 17 4 2 2 1 1 20 15 9 5 2 1 1 1 3 3: 21.5 0.9 15 3.5 1.8 1.8 0.9 0.9 2021 Jun 25;118(25):431. doi: 10.3238/arztebl.m2021.0257. official website and that any information you provide is encrypted Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Table 1. Oueijan RI, Hill OR, Ahiawodzi PD, Fasinu PS, Thompson DK. In: Jameson J, Fauci AS, Kasper DL, et al., eds. 2021;184(6):11941195. National Library of Medicine Epub 2022 Jun 13. Unauthorized use of these marks is strictly prohibited. Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. . Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. Dermatol Ther. Epub 2022 Feb 9. Treatment was initiated with systemic corticosteroid therapy - hydrocortisone hemisuccinate 200 mg/day for 7 days, and loratadine 10 mg 2 times a day. PMC MeSH (2021) 35:e5468. Rybak-d'Obyrn J, Placek W, Owczarczyk-Saczonek A, Derkaczew M, Joniec E, Hofman R, Stompr M. Clin Cosmet Investig Dermatol. Women are 50% more likely to develop pityriasis rosea. In approximately 50% of people with pityriasis rosea, the patches itch. doi: 10.7759/cureus.22414. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Drago F, Ciccarese G, Javor S, et al. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. doi: 10.1016/j.jdcr.2018.04.002, 12. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Disclaimer. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, et al. J Med Virol 2021; 93: 18501851. Cazzato G, Ambrogio F, Pisani MC, Colagrande A, Arezzo F, Cascardi E, Dellino M, Macorano E, Trilli I, Parente P, Lettini T, Romita P, Marzullo A, Ingravallo G, Foti C. Vaccines (Basel). American Academy of Dermatology's National Library of Dermatologic Teaching Slides. JAAD Case Rep 2018; 4: 800801. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. (No.) However, the studies dont conclusively prove that COVID-19 causes pityriasis rosea. Authors Jordan E Buckley 1 , Laura N Landis 2 , Ronald P Rapini 1 Affiliations doi: 10.1007/s10103-019-02783-8, 16. Before Federal government websites often end in .gov or .mil. MeSH Similar to other viral outbreaks, people can experience flu-like symptoms like a fever, aches, or a runny nose when the herald patch shows up, Lam says, though I was lucky enough to skip that step. Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). Your rash looks infected (red, purple, gray or white skin; irritation and swelling). Unable to load your collection due to an error, Unable to load your delegates due to an error. The .gov means its official. Do the medications have any side effects? Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. Bethesda, MD 20894, Web Policies And the itch usually only lasts for a few days mine finally let up around day seven but the rash can leave behind dark marks that eventually resolve on their own, Lam says. Dermatol Res Pract. (2021). In: Knoop KJ, Stack LB, Storrow AB, et al., eds. 2023 Feb 9;11(2):397. doi: 10.3390/vaccines11020397. Authors Elina Khattab 1 , Eirini Christaki 2 , Constantinos Pitsios 1 Affiliations 1 Medical School, University of Cyprus, Nicosia, Cyprus. "Other treatments including phototherapy or oral medications can be considered for extensive or persistent cases, [and] some small case studies support the use of oral antivirals like acyclovir or oral anti-inflammatory antibiotics erythromycin," King explains. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. Br J Dermatol. PMC How can you tell that I have pityriasis rosea? -, Neoh CY, Tan AW, Mohamed K, et al. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature JAAD Int. 2023 Cond Nast. Pityriasis rosea usually resolves on its own without treatment in most cases, King says, but topical corticosteroids can be used for itchy control if necessary, which is what I used. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage lines, most appreciable on the upper portion of the chest. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). Some patients may have a cold before the rash. 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. An official website of the United States government. doi: 10.1111/dth.15601. Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. Although the exact pathophysiologic mechanisms of PR after vaccination remain unclear, immune responses to COVID-19 vaccines and disruption of T-cell mediated control of latent infections were implicated (12, 1518). Yes, There Is a Correct Order for Everything You Do in the Shower, Each Zodiac Sign's Unique Personality Traits, Swoopy 1960s Hair Was Everywhere at the SAG Awards, Christina Aguilera Opened Up About Getting Injections and Why She Doesn't Care If People Judge Her, "I think we all can rely on a little help. A 3-cm oval plaque with peripheral scale, larger, MeSH Alamri A, Alghamdi Y, Alamri SJ, Althaqafi MK, AlQurashi W, Bader BA, Mohanna AT, Almahdi B. Cureus. Now watch a pro surfer's entire daily routine: Follow Allure onInstagram andTwitter, orsubscribe to our newsletter to stay up to date on all things beauty. Advertising on our site helps support our mission. Pityriasis rosea is a common condition that causes discolored patches on your skin. An official website of the United States government. "There's some emerging data where there are certain skin rashes that seem to be more associated with the COVID vaccine, and pityriasis rosea is one them. Epub 2021 Aug 7. Although the exact pathogenesis of PR is unknown, current evidence suggests that an inflammatory reaction due to a viral trigger may lead to the cutaneous manifestations. Bethesda, MD 20894, Web Policies How do dermatologists treat pityriasis rosea? Federal government websites often end in .gov or .mil. J Med Virol. doi: 10.1016/j.jaad.2020.04.094, 8. (Unfortunately, I scratched my rash until it bled, so my hyperpigmentation may linger.). Careers. They develop in a pattern that resembles sagging Christmas tree branches. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. While you don't need to treat the rash, some patients ask for treatment to take care of the following. Get useful, helpful and relevant health + wellness information. We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. Pityriasis Lichenoides. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. Epub 2020 Jun 29. Among patients who received inactivated vaccines, another case of PR-like eruption was reported four days after the first dose of CoronaVac (SinoVac) (1). 2021 Aug;185(2):e34. Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. Some people develop a few large patches on their skin. If you develop symptoms of pityriasis rosea while pregnant, contact your healthcare provider right away. KL and KP collated resources. The condition is more prevalent in spring and fall. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. Epub 2021 Jun 10. Cutaneous Eruptions in the Course of COVID-19 Among Geriatric Patients in a Nursing Home in Poland. Would you like email updates of new search results? These types cannot cause cold sores or genital herpes. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Cured meats with nitrates, such as hot dogs. The https:// ensures that you are connecting to the (b) haematoxylineosin, original magnification 20. Federal government websites often end in .gov or .mil. eCollection 2021. Pityriasis Rosea Induced by COVID-19 Vaccination Eur J Case Rep Intern Med. Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). However, if it does, the symptoms may last for a longer period. This reaction is self-limited and resolves in an average of 5.6 weeks. (2021) 35:e4913. The authors have no conflicts of interest to declare. F. Drago, G. Ciccarese, A. Parodi However, there isnt enough research to determine that stress may cause pityriasis rosea. Some people see the rash disappear within 6 to 8 weeks, but it can take 5 months or longer for the skin to clear. Another skin condition identified in the study were "vesicular eruptions" seen in 9 per cent of cases. 1. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). From grooming sets to self-care gadgets, we've got them covered. How quickly did it come on, and did my boyfriend also have it? Children often get infected when someone sneezes or kisses them. The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. doi: 10.1111/dth.13878, 10. N Engl J Med 2020; 383: 26032615. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. . Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same . (2006) 12:1. doi: 10.5070/D380D8301D, 11. Pityriasis is linked mainly with herpesviruses 6 and 7; only a . Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. Would you like email updates of new search results? Bookshelf Though there's no single-known cause, it may be brought on by a drug interaction, or the reactivation of herpes simplex virus 6 or 7. This site needs JavaScript to work properly. official website and that any information you provide is encrypted "Any type of stress on the body can sometimes [cause them, and] any vaccine, not just the COVID one.". Federal government websites often end in .gov or .mil. Histopathological Patterns of Cutaneous Adverse Reaction to Anti-SARS-CoV-2 Vaccines: The Integrative Role of Skin Biopsy.
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